Understanding the role of chronopharmacology for drug optimization: what do we know?

A Fujimura, K Ushijima - Expert Review of Clinical Pharmacology, 2023 - Taylor & Francis
… of drugs in bile also shows circadian variation. However, … 09:00 in patients with cancer who
had undergone percutaneous … as it reports that the biliary excretion of flomoxef is greater after …

Pharmacokinetics-based chronotherapy

D Lu, Z Wang, B Wu - Current Drug Metabolism, 2022 - ingentaconnect.com
… to a daily variation in drug exposure caused by circadian … , probably resulting from circadian
variations in OCT2mediated … Biliary excretion of flomoxef is greater in the early rest phase …

Role of pharmacokinetics in chronotherapeutics

D Lu, Y Wang, M Chen, H Zhao, D Dong - Circadian Pharmacokinetics, 2020 - Springer
circadian variations when drugs are administered via oral route, but no … patients receiving
percutaneous biliary drainage, biliary excretion of drugs such as ampicillin and flomoxef